Análise da saliva nas desordens sistêmicas

José Alexandre da Rocha Curvelo, Dennis de Carvalho Ferreira, Elicardo Alves de Souza Gonçalves, Martinna de Mendonça e Bertolini, Liana Bastos Freitas Fernandes

Resumo

Introdução: A saliva humana possui um amplo grupo de constituintes proteicos e não proteicos que possuem um imenso potencial informativo para a detecção de doenças sistêmicas. De forma geral, as alterações sistêmicas alteram o funcionamento das glândulas salivares de forma direta ou indireta, e essas alterações, ao serem detectadas e mensuradas, podem contribuir para o diagnóstico precoce de doenças. O objetivo deste estudo é revisar a literatura sobre as possíveis aplicações diagnósticas fornecidas pela análise da saliva e de suas alterações perante as desordens sistêmicas. Conclusão: Concluiu-se que a análise do fluido salivar com finalidade diagnóstica se fundamenta na possível correlação entre os constituintes salivares e os parâmetros bioquímicos tradicionais, como do plasma. Dentre as possíveis aplicações diagnósticas da saliva, pode-se destacar a comprovação de desordens hereditárias, a identificação e monitoramento de alterações imunológicas o diagnóstico e acompanhamento de processos infecciosos, além do controle da resposta imunológica e dos níveis hormonais.

Palavras-chave

Saliva ;Diagnóstico;Síndrome de Imunodeficiência Adquirida.

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Referências

Xie H, Rhodus NL, Griffin RJ, Carlis JV, Griffin TJ. A catalogue of human saliva proteins identified by free flow Eelectrophoresis-based peptide separation and tandem mass spectrometry. mol cell Proteomics 2005 nov; 4(11):1826–30

Dawes C. Circadian rhythms in the flow rate and composition of unstimulated and stimulated human submandibular saliva. J Physiol. 1975 Jan; 244(2): 535-48

Streckfus CF, Bigler LR. Saliva as a diagnostic fluid. oral Diseases 2002 mar; 8(2): 69–76 Kaufman e, lamster iB. the diagnostic applications of saliva- a review. crit rev oral Biol med 2002; 13(2): 197-212

Wong dt. salivary diagnostics powered by nanotechnologies, proteomics and genomics. J Am Dent Assoc 2006 mar; 137(3): 313-21.

Pedersen Am, Bardow A, Jensen sB et al. saliva and gastrointestinal functions of taste, mastication, swallowing and digestion, oral Diseases 2002 may; 8(3): 117– 29

ceder o, van dijken J, ericson t, Kollberg H. ribonuclease in different types of saliva from cystic fibrosis patients. Acta Paediatr scand.1985 Jan; 74(1): 102-6

Aps JK, delanghe J, martens lc. salivary electrolyte concentrations are associated with cystic fibrosis transmembrane regulator genotypes. clin chem lab med. 2002 Apr; 40(4): 345-50

Boat TF, Wiesman UN, Pallavicinni JC. Purification and properties of the calciumprecipitable protein in submaxillary saliva of normal and cystic fibrosis subjects. Pediatr res.1974 may; 8(5): 531-9

mangos JA, donnelly WH. isolated Parotid Acinar cells from Patients with cystic Fibrosis. morphology and composition. J Dent res1981 Jan; 60(1): 19-25

Aubert B, cochet c, souvignet c et al. Saliva from cystic fibrosis patients contains an unusual form of epidermal growth factor. Biochem Biophys res commun. 1990 Aug 16; 170(3): 1144-50.

Ai-Bayaty HF, Aidred mJ, Walker dm, et al. salivary and serum antibodies to gliadin in the diagnosis of celiac disease. Journal of oral Pathology & medicine 1989 dec; 18(10): 578–81.

Hakeem V, Fifield R, al-Bayaty HF et al. salivary igA antigliadin antibody as a marker for coeliac disease. Arch Dis child. 1992 Jun;67(6):724-7

lenander-lumikari m, ihalin r, lahteenoja H. changes in whole saliva in patients with celiac disease. Archives of oral Biology 2000 may; 45(5): 347-54.

Elias LLK, Castro M. Diagnóstico da forma não clássica da deficiência de 21-Hidroxilase. Redefinição de critérios após estudos moleculares. Arq Bras endocrinol metab 2003 out; 47(5): 511-3

Guechot J, Fiet J, Gourmelen m, et al. radioimmunoassay of salivary l7 alpha-hydroxyprogesterone. values obtained in healthy subjects and in patients treated for congenital hyperplasia of the adrenal glands. Ann Biol clin 1985; 43(4): 333-7

Yarak s, Bagatin e, Hassun Km, Parada moAB, talarico Filho s. Hiperandrogenismo e pele: síndrome do ovário policístico e resistência periférica à insulina. Ann Bras dermatol. 2005 jul-ago; 80(4): 395-410

Killeen AA, Hanson nQ, eklund r, cairl cJ, eckfeldt JH. Prevalence of nonclassical congenital adrenal hyperplasia among women self-referred for electrolytic treatment of hirsutism. Am J med Genet 1992 Jan; 42(2): 197-200

nóbrega lHc, lima JG, nóbrega mlc, BritoAls, mendonça rP. Hiperplasia Adrenal congênita: dosagem da 17-Hidroxiprogesterona Basal para seleção e casos para realização do teste de estímulo com ActH sintético. rBGo 2004: 26 (4):295-8

sreebny lm, Zhu WX. the use of whole saliva in the differential diagnosis of sjögren’s syndrome. Adv Dent res. 1996; 10(1): 17-24.

Kalk WWi, vissink A, stegenga B, Bootsma H, Amerongen Avn & Kallenberg cGm. sialometry and sialochemistry: a non-invasive approach for diagnosing sjögren’s syndrome. Ann rheum dis 2002 Feb; 61(2): 137-44

slomiany Bl, Kosmala m, nadziejko c et al. lipid composition and viscosity of parotid saliva in sjögren syndrome in man. Arch oral Biol 1986; 31(10): 699-702

van der reijden WA, van der Kwaak Js, veerman ec et al. Analysis of the concentration and output of whole salivary constituents in patients with sjögren’s syndrome. eur J oral sci. 1996; 104(4):335-40

Friberg B, Jonsson r, linde A. salivary kallikrein in sjögren’s syndrome. clin exp rheumatol. 1988 Apr-Jun; 6(2): 135-8

soto-rojas Ae, Kraus A. the oral side of sjögren syndrome. diagnosis and treatment:A review. Archives of medical research 2002 mar-Apr; 33(2) 95–106

miziara id, Ximenes-Filho JA, ribeiro Fc, Brandão Al. Acometimento oral do Pênfigo Vulgar.Rev Bras Otorrinolaringol. 2003;69(3): 327:31

Andreadis d, lorenzini G, drakoulakos d, et al. detection of pemphigus desmoglein and desmoglein 3 autoantibodies and pemphigoid BP180 autoantibodies in saliva and comparison with serum value. eur J oral sci 2006 oct; 114(5): 374-80.

shpitzer t, Bahar G, Freinmesser r, nagler rm. A comprehensive salivary analysis for oral cancer diagnosis. J cancer res clin oncol 2007 sep; 133(9): 613-7

ohshiro K, rosenthal d; Koomen Jm et al. Pre-analytic saliva processing affect proteomic results and biomarker screening of head and neck squamous carcinoma. int J oncol 2007 mar; 30(3): 743-9.

tavassoli m, Brunel n, maher r, Johnson nW, soussi t . P53 antibodies in the saliva of patients with squamous cell carcinoma of the oral cavity. int J cancer 1998 oct; 78(3): 390-1.

Bigler rl, streckfus cF, copeland l et al. the potential use of saliva to detect recurrence of disease in women with breast carcinoma. J oral Pathol med 2002 Aug; 31(7): 421-3. .

sidransky d. emerging molecular markers of cancer. nature reviews cancer 2002 mar; 2(3): 210-19

streckfus c, Bigler l. the use of soluble, salivary c-erbB-2 for the detection and post-operative follow-up of breast cancer in women: the results of a five-year translational research study. Adv Dent res 2005 Jun;18(1): 17-24

tiwari sK, Khan AA, Ahmed Ks, et al. rapid diagnosis of Helicobacter pylori infection in dyspeptic patients using salivary secretion: a non-invasive approach. singapore med J 2005 may; 46(5) : 224-8

reilly tG, Poxon v, sanders dsA, elliott tsJ, Walt rP. comparison of serum, salivary, and rapid whole blood diagnostic tests for Helicobacter pylori and their validation against endoscopy based tests. Gut 1997 Apr; 40(4): 454-8.

mager dl, Haffajee1 Ad,devlin Pm, norris cm, Posner mr, Goodson Jm. the salivary microbiota as a diagnostic indicator of oral cancer: A descriptive, non randomized study of cancer-free and oral squamous cell carcinoma subjects. Journal of translational medicine 2005 Jul 7; 3:27

mortimer PP, Parry Jv. the use of saliva for viral diagnosis and screening. epidemiol infect. 1988 oct; 101(2): 197-201

stuart Jm, majeed FA, cartwright KA et al. salivary antibody testing in a school outbreak of hepatitis A. epidemiol infect. 1992 Aug;109(1): 161-6.

el medany om, el din Abdel Ks, Abu shady eA et al. chronic liver disease and hepatitis c virus in egyptian patients. Hepatogastroenterology. 1999 may-Jun; 46(27): 1895-903

thieme t, Piacentini s, davidson s et al. determination of measles, mumps, and rubella immunization status using oral fluid samples. JAmA. 1994 Jul; 272(3): 219-21

Jayashree s, Bhan mK, Kumar r, raj P, Glass r, Bhandari n. serum and salivary antibodies as indicators of rotavirus infection in neonates J infect dis. 1988 nov; 158(5):1117-20

cuzzubbo AJ, vaughn dW, nisalak A , suntayakorn s, Aaskov J, devine Pl. detection of specific antibodies in saliva during dengue Infection. J Clin Microbiol 1998 dec; 36(12): 3737–9

Balmaseda A, Guzman mG, Hammond s. diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva. clin Diagn lab immunol. 2003 mar; 10(2): 317–22

Mizuno Y, Kotaki A, Harada F, Tajima S, Kurane I, Takasaki T. Confirmation of dengue virus infection by detection of dengue virus type 1 genome in urine and saliva but not in plasma.trans r soc trop med Hyg. 2007 Jul;101(7):738-9.

Franco-Paredes c, tellez i, del rio c. rapid Hiv testing: a review of the literature and implications for the clinician. curr Hiv/Aids rep.2006 nov; 3(4): 169-75.

Glick m. rapid Hiv testing in the dental setting. J Am Dent Assoc 2005 sep; 136(9): 1206-8.

tabak lA. A revolution in biomedical assessment: the development of salivary diagnostics. J Dent educ 2001 dec; 65(12): 1335–9

laine mA, ojanotko Ao. Progesterone metabolism in human saliva in vitro. J steroid Biochem mol Biol. 1999 Jul-Ago; 70(1-3): 109-13

Drummer OH. Drug testing in oral fluid. clin Biochem rev 2006 Aug; 27(3): 14759

chiappin s, Antonelli G, Gatti r, de Palo eF. saliva specimen: a new laboratory tool for diagnostic and basic investigation. clinica chimica Acta 2007 Aug; 383(1-2): 3040.

Hoek GH, Brand Hs, veerman eci, nieuw Amerongen Av. toothbrushing affects the protein composition of whole saliva. eur J oral sci 2002; 110: 480–481

Petricoin eF, Zoon Kc, Kohn ec, J. Barrett c, liotta lA. clinical proteomics: translating benchside promise into bedside reality. nature rev Drug Discov 2002 sep; 1(9): 683-95.

Wulfkuhle Jd, liotta lA, Petricoin eF, Proteomica applications for the early detection of cancer. nature reviews cancer 2003 Apr:3(4): 267-75.

Hodgson TA, Naidoo S, Chidzonga M, Ramos-Gomes F, Shiboski C. Identification of oral health care needs in children and adults, management of oral diseases. Adv Dent res 2006 Apr; 19(1): 106-17.


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